GRAP2

Across TCGA cell cohorts, GRAP2 mutation is significantly associated with the mutation status of many other genes, with 2,386 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRAP2-associated genes across cancer lineages are ZNF354A, GRM3, and CDH1. Each is linked with GRAP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both GRAP2-to-partner and partner-to-GRAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF354A grouped by GRAP2-low versus GRAP2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAP2→partner) and Y-score (partner→GRAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZNF354A →	+4.392	+4.392	.009	.009	1	4
BLOOD_Leukemia	GRM3 →	+4.157	+5.430	<.001	<.001	1	4
SKIN	CDH1 →	+4.977	+5.638	<.001	<.001	1	3
SKIN	EPHA3 →	+2.977	+4.392	.005	.005	1	3
BLOOD_Lymphoma	INSRR →	+3.362	+4.754	.002	.002	1	3
BLOOD_Lymphoma	ATP6V0A1 →	+5.584	+5.014	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,386 associations by consensus.

ZNF354A by GRAP2 expression — SKIN

Explore this box plot interactively →