GRAP2

Across TCGA pan-cancer cohorts, GRAP2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated GRAP2 data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GRAP2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GRAP2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

HNSC, UVM, and CESC are the cancer types where GRAP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.675	0.531	<.001	116	view →
UVM	OS	Median	All	0.416	0.797	<.001	111	view →
CESC	DFS	Median	All	0.838	0.633	<.001	84	view →
SKCM	OS	Median	All	0.417	0.263	<.001	65	view →
LUAD	DFS	Median	All	0.741	0.597	<.001	63	view →
UCEC	OS	Tertile	III,IV	0.749	0.363	.001	48	view →
LGG	OS	Median	All	0.852	0.934	<.001	36	view →
PAAD	DFS	Median	II,III,IV	0.355	0.251	.005	34	view →
KIRC	DFS	Median	II,III,IV	0.632	0.353	.002	32	view →
BRCA	DFS	Median	All	0.601	0.464	<.001	32	view →
SARC	OS	Tertile	All	0.620	0.371	<.001	23	view →
THYM	OS	Median	All	1.000	0.709	<.001	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GRAP2–HNSC (DFS)

Open the HNSC breakdown →