GRAP2

Across TCGA pan-cancer cohorts, GRAP2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GRAP2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GRAP2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GRAP2 is over-expressed in tumor, although a few such as BLCA and LUSC show the opposite, repressed pattern.

KIRC, BLCA, and LUSC are the cancer types where GRAP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GRAP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.937	<.001	10	view →
BLCA	All	All	−0.735	<.001	10	view →
LUSC	All	II,III,IV	−1.066	<.001	8	view →
LUAD	Female	II,III,IV	−0.925	<.001	8	view →
COAD	Female	II,III,IV	−0.617	<.001	8	view →
THCA	Female	II,III,IV	−0.547	<.001	7	view →
UCEC	All	All	−0.696	<.001	6	view →
STAD	All	II,III,IV	+0.510	.032	4	view →
LIHC	All	II,III,IV	+0.356	.024	2	view →
KICH	All	All	−0.262	.024	2	view →
PRAD	All	All	−0.226	.025	2	view →
BRCA	All	II,III,IV	−0.192	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GRAP2–KIRC

Open the KIRC breakdown →