GPX8

Across TCGA patient cohorts, GPX8 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPX8-associated genes across cancer lineages are RNU6-1252P, FAM236B, and RN7SL248P. Each is linked with GPX8 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPX8-to-partner and partner-to-GPX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1252P grouped by GPX8-low versus GPX8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX8→partner) and Y-score (partner→GPX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1252P →	+0.526	+7.741	<.001	.009	3	2
BRCA	FAM236B →	+0.119	+8.055	<.001	.007	3	1
UCEC	RN7SL248P →	+0.131	+4.400	<.001	.006	3	1
UCEC	RNU6-1290P →	+0.411	+4.727	<.001	.003	3	1
UCEC	RNA5SP77 →	+0.995	+3.253	<.001	.005	3	1
UCEC	RNU6-242P →	+0.377	+3.302	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

RNU6-1252P by GPX8 expression — COAD

Explore this box plot interactively →