GPT

Across TCGA cell cohorts, GPT mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPT-associated genes across cancer lineages are ELOA3DP, CCDC172, and OPRPN. Each is linked with GPT in more than 2 cancer types. Because this analysis shows association rather than direction, both GPT-to-partner and partner-to-GPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA3DP grouped by GPT-low versus GPT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPT→partner) and Y-score (partner→GPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ELOA3DP →	+0.030	+3.103	<.001	.004	3	3
SKIN	CCDC172 →	+0.006	+5.415	<.001	.004	3	2
URINARY_TRACT	OPRPN →	+0.060	+5.087	<.001	.004	3	1
URINARY_TRACT	CA5A →	+0.020	+5.087	<.001	.004	3	1
SKIN	CETN1 →	+0.013	+6.022	<.001	.001	3	1
SKIN	HTR3C →	+0.053	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

ELOA3DP by GPT expression — LARGE_INTESTINE

Explore this box plot interactively →