GPT

Across TCGA pan-cancer cohorts, GPT RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GPT’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GPT RNA is repressed in tumor relative to normal tissue. In most cancer types GPT is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and KIRP are the cancer types where GPT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−3.088	<.001	12	view →
HNSC	All	IV	−2.185	<.001	12	view →
KIRP	All	IV	−3.899	<.001	11	view →
BRCA	All	III,IV	−1.533	<.001	8	view →
KICH	All	All	−1.928	<.001	6	view →
LUSC	All	All	+0.471	<.001	6	view →
CHOL	Male	All	−3.743	<.001	5	view →
READ	All	All	−3.056	<.001	5	view →
THCA	All	All	+0.633	<.001	5	view →
LUAD	All	All	+0.536	<.001	4	view →
LIHC	All	II,III,IV	−1.030	.012	2	view →
PRAD	All	All	−0.289	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GPT–COAD

Open the COAD breakdown →