GPS2

Across TCGA cell cohorts, GPS2 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. CNS shows the largest number of these associations.

The most reproducible GPS2-associated genes across cancer lineages are TEX43, FCN2, and NXPE4. Each is linked with GPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPS2-to-partner and partner-to-GPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX43 grouped by GPS2-low versus GPS2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPS2→partner) and Y-score (partner→GPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TEX43 →	+0.135	+4.981	.008	.008	3	2
LARGE_INTESTINE	FCN2 →	+0.052	+5.415	<.001	.004	3	1
BLOOD_Leukemia	NXPE4 →	+0.020	+4.276	<.001	.007	3	1
BLOOD_Leukemia	OR10T2 →	+0.584	+4.276	.005	.007	3	1
BLOOD_Leukemia	ANGPTL5 →	+0.022	+4.276	.007	.007	3	1
BLOOD_Leukemia	C3orf85 →	+0.044	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

TEX43 by GPS2 expression — CNS

Explore this box plot interactively →