GPS2

Across TCGA pan-cancer cohorts, GPS2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of GPS2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GPS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPS2 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where GPS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.523	<.001	10	view →
COAD	All	II,III,IV	+0.404	<.001	9	view →
LIHC	Female	II,III,IV	+0.790	<.001	8	view →
HNSC	Male	III,IV	+0.525	<.001	8	view →
KICH	Female	All	−0.729	<.001	7	view →
BRCA	All	All	−0.501	<.001	6	view →
STAD	All	II,III,IV	+0.367	.002	5	view →
THCA	All	All	−0.270	.009	4	view →
CHOL	Male	All	+1.871	<.001	3	view →
ESCA	All	II,III,IV	+0.684	.022	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

GPS2–KIRC

Open the KIRC breakdown →