GPRC5C

Across TCGA patient cohorts, GPRC5C mutation is significantly associated with the RNA expression of many other genes, with 4,315 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPRC5C-associated genes across cancer lineages are COPB2, TMED7-TICAM2, and DCAF11. Each is linked with GPRC5C in more than 3 cancer types. Because this analysis shows association rather than direction, both GPRC5C-to-partner and partner-to-GPRC5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPB2 grouped by GPRC5C-low versus GPRC5C-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPRC5C→partner) and Y-score (partner→GPRC5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	COPB2 →	+0.374	+3.375	.006	.005	3	3
COAD	TMED7-TICAM2 →	+0.307	+3.452	<.001	.003	3	3
UCEC	DCAF11 →	+0.314	+3.470	.006	.002	3	3
SKCM	LACTB →	+0.659	+3.725	<.001	<.001	3	3
UCEC	KCTD9 →	+0.640	+2.148	<.001	<.001	3	3
UCEC	TMEM245 →	+0.464	+2.447	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,315 associations by consensus.

COPB2 by GPRC5C expression — COAD

Explore this box plot interactively →