GPRC5C

Across TCGA pan-cancer cohorts, GPRC5C RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of GPRC5C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GPRC5C RNA is repressed in tumor relative to normal tissue. In most cancer types GPRC5C is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LUSC are the cancer types where GPRC5C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPRC5C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.033	<.001	11	view →
KICH	All	III,IV	−1.991	<.001	10	view →
LUSC	Male	II,III,IV	−1.389	<.001	4	view →
PAAD	All	All	+1.320	.010	4	view →
LIHC	All	All	+0.466	<.001	3	view →
PRAD	All	All	−0.288	.042	2	view →
STAD	All	IV	−1.523	.028	1	view →
BLCA	All	III,IV	+1.350	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

GPRC5C–KIRC

Open the KIRC breakdown →