GPRC5C

Across TCGA pan-cancer cohorts, GPRC5C RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated GPRC5C data layer compared with 3 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher GPRC5C RNA is associated with better overall survival. In most high-consensus cancer types, elevated GPRC5C expression acts as an unfavorable survival marker, although some lineages such as MESO and SCLC show a favorable association.

MESO, ACC, and SCLC are the cancer types where GPRC5C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	II,III,IV	0.529	0.275	<.001	88	view →
ACC	DFS	Tertile	All	0.286	0.741	<.001	63	view →
SCLC	DFS	Tertile	All	0.729	0.449	<.001	56	view →
KIRC	OS	Median	All	0.848	0.762	<.001	50	view →
BLCA	OS	Tertile	II,III,IV	0.639	0.421	.007	40	view →
CHOL	DFS	Tertile	All	0.291	0.846	.001	27	view →
HNSC	DFS	Quartile	All	0.561	0.796	.004	20	view →
LGG	OS	Quartile	All	0.805	0.919	.002	19	view →
ESCA	OS	Tertile	All	0.427	1.000	.011	18	view →
KICH	DFS	Median	II,III,IV	1.000	0.399	.002	17	view →
LIHC	DFS	Quartile	All	0.327	0.508	.004	16	view →
SKCM	OS	Median	All	0.752	0.813	.013	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GPRC5C–MESO (OS)

Open the MESO breakdown →