GPRC5C

Across TCGA patient cohorts, GPRC5C mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPRC5C-associated genes across cancer lineages are Notch1, PCNA, and Caspase-7-cleavedD198. Each is linked with GPRC5C in more than 1 cancer types. Because this analysis shows association rather than direction, both GPRC5C-to-partner and partner-to-GPRC5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by GPRC5C-low versus GPRC5C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPRC5C→partner) and Y-score (partner→GPRC5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.182	+2.598	<.001	.005	3	2
UCEC	PCNA →	+0.195	+1.415	.016	.046	3	2
SKCM	Caspase-7-cleavedD198 →	+0.531	+3.016	.030	.018	3	2
UCEC	Cyclin-B1 →	+0.779	+2.169	<.001	.003	3	2
UCEC	14-3-3_beta →	-0.111	-2.649	.003	<.001	3	1
UCEC	FoxM1 →	+0.260	+1.884	.007	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Notch1 by GPRC5C expression — UCEC

Explore this box plot interactively →