GPRC5C

Across TCGA cell cohorts, GPRC5C mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPRC5C-associated genes across cancer lineages are COX6A2, TBXT, and PPDPFL. Each is linked with GPRC5C in more than 1 cancer types. Because this analysis shows association rather than direction, both GPRC5C-to-partner and partner-to-GPRC5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6A2 grouped by GPRC5C-low versus GPRC5C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPRC5C→partner) and Y-score (partner→GPRC5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COX6A2 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TBXT →	+0.622	+3.660	<.001	.005	3	1
LARGE_INTESTINE	PPDPFL →	+0.034	+3.217	<.001	.006	3	1
LARGE_INTESTINE	ASCL3 →	+0.127	+3.617	.008	.004	3	1
LARGE_INTESTINE	FAM9B →	+0.383	+3.716	.007	.003	3	1
LARGE_INTESTINE	PRR23B →	+0.003	+3.217	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

COX6A2 by GPRC5C expression — LARGE_INTESTINE

Explore this box plot interactively →