GPR83

Across TCGA patient cohorts, GPR83 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR83-associated genes across cancer lineages are PDCD4, PCNA, and eEF2. Each is linked with GPR83 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR83-to-partner and partner-to-GPR83 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by GPR83-low versus GPR83-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR83→partner) and Y-score (partner→GPR83) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PDCD4 →	-0.379	-2.584	.042	.011	3	3
UCEC	PCNA →	+0.420	+3.321	<.001	.009	3	3
SKCM	eEF2 →	+0.383	+2.321	.012	.033	3	2
UCEC	Cyclin-B1 →	+0.644	+3.169	.013	.018	3	2
UCEC	TIGAR →	+0.166	+2.611	.019	.006	3	2
UCEC	4E-BP1 →	+0.363	+3.029	.004	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PDCD4 by GPR83 expression — SKCM

Explore this box plot interactively →