GPR83

Across TCGA pan-cancer cohorts, GPR83 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of GPR83’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GPR83 RNA is repressed in tumor relative to normal tissue. In most cancer types GPR83 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and KIRC are the cancer types where GPR83 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR83 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.344	<.001	10	view →
THCA	Male	III,IV	−2.705	<.001	9	view →
KIRC	Male	II,III,IV	−0.241	<.001	6	view →
BRCA	Female	All	−0.190	.002	6	view →
LUSC	All	II,III,IV	+0.257	.004	5	view →
COAD	Male	II,III,IV	−0.141	.013	3	view →
LIHC	All	All	−0.109	<.001	3	view →
UCEC	All	All	+0.573	.009	2	view →
KIRP	All	All	−0.153	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

GPR83–KICH

Open the KICH breakdown →