GPR83

Across TCGA pan-cancer cohorts, GPR83 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated GPR83 data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher GPR83 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GPR83 expression acts as an unfavorable survival marker, although some lineages such as SCLC and READ show a favorable association.

SCLC, LUAD, and READ are the cancer types where GPR83 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	III,IV	0.710	0.297	.001	48	view →
LUAD	DFS	Median	III,IV	0.512	0.814	.003	43	view →
READ	OS	Quartile	II,III,IV	0.719	0.353	.001	33	view →
KIRC	OS	Tertile	All	0.520	0.687	.001	32	view →
BLCA	DFS	Tertile	IV	0.642	0.363	.001	32	view →
UVM	OS	Median	III,IV	0.240	0.836	.001	24	view →
COAD	OS	Median	II,III,IV	0.488	0.698	.013	22	view →
CHOL	OS	Median	All	0.876	0.262	.001	18	view →
LIHC	DFS	Median	III,IV	0.577	0.223	.001	15	view →
KICH	OS	Quartile	III,IV	0.454	1.000	.034	13	view →
UCS	DFS	Median	III,IV	0.450	0.142	.035	10	view →
BRCA	OS	Tertile	II,III,IV	0.885	0.942	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GPR83–SCLC (DFS)

Open the SCLC breakdown →