GPR83

Across TCGA cell cohorts, GPR83 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GPR83-associated genes across cancer lineages are KRT73, ZNF705G, and SULT6B1. Each is linked with GPR83 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR83-to-partner and partner-to-GPR83 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT73 grouped by GPR83-low versus GPR83-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR83→partner) and Y-score (partner→GPR83) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KRT73 →	+0.069	+4.215	<.001	.002	3	1
LUNG_NSCLC_LUAD	ZNF705G →	+0.004	+4.681	<.001	.003	3	1
LARGE_INTESTINE	SULT6B1 →	+0.055	+4.977	<.001	.007	3	1
LARGE_INTESTINE	TECRL →	+0.026	+4.977	<.001	.007	3	1
SKIN	H3-4 →	+0.204	+4.237	<.001	<.001	3	1
SKIN	MYMK →	+0.038	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

KRT73 by GPR83 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →