GPR68

Across TCGA patient cohorts, GPR68 mutation is significantly associated with the RNA expression of many other genes, with 500 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR68-associated genes across cancer lineages are RNU6-1118P, SOCS5P1, and GLRXP2. Each is linked with GPR68 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR68-to-partner and partner-to-GPR68 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1118P grouped by GPR68-low versus GPR68-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR68→partner) and Y-score (partner→GPR68) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-1118P →	+0.143	+4.718	<.001	.003	3	2
BLCA	SOCS5P1 →	+0.044	+4.492	<.001	.005	3	2
CESC	GLRXP2 →	+0.178	+5.539	<.001	.004	3	2
PRAD	RNU7-52P →	+0.503	+7.939	<.001	.008	3	2
SKCM	OR5D17P →	+0.041	+4.282	<.001	.009	3	2
BLCA	MIR6794 →	+0.278	+6.318	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 500 associations by consensus.

RNU6-1118P by GPR68 expression — BLCA

Explore this box plot interactively →