GPR68

Across TCGA patient cohorts, GPR68 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR68-associated genes across cancer lineages are ATM, MSH2, and p27_pT157. Each is linked with GPR68 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR68-to-partner and partner-to-GPR68 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GPR68-low versus GPR68-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR68→partner) and Y-score (partner→GPR68) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.569	-2.459	.009	.020	3	2
UCEC	MSH2 →	-0.396	-3.160	<.001	.019	3	1
UCEC	p27_pT157 →	-0.061	-2.459	.029	.020	3	1
UCEC	p62 Lck ligand →	+0.322	+3.179	.040	.010	3	1
UCEC	AMPK_pT172 →	+0.484	+3.169	.014	.018	3	1
UCEC	Annexin-1 →	+0.806	+3.189	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ATM by GPR68 expression — UCEC

Explore this box plot interactively →