GPR68

Across TCGA cell cohorts, GPR68 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,496 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible GPR68-associated GO terms across cancer lineages are Regulation of protein localization to mitochondrion, Anaphase-promoting complex-dependent catabolic process, and Regulation of fibroblast proliferation. Each is linked with GPR68 in more than 10 cancer types. Because this analysis shows association rather than direction, both GPR68-to-partner and partner-to-GPR68 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to mitochondrion grouped by GPR68-low versus GPR68-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR68→partner) and Y-score (partner→GPR68) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of protein localization to mitochondrion →	+0.115	+1.780	<.001	<.001	3	11
OESOPHAGUS	Anaphase-promoting complex-dependent catabolic process →	+0.083	+0.981	.009	<.001	3	10
PANCREAS	Regulation of fibroblast proliferation →	+0.125	+0.982	<.001	<.001	3	10
PANCREAS	Regulation of response to cytokine stimulus →	+0.059	+0.826	.004	.005	2	11
PANCREAS	Regulation of ubiquitin-dependent protein catabolic process →	+0.067	+1.303	<.001	<.001	3	10
OESOPHAGUS	Regulation of tumor necrosis factor-mediated signaling pathway →	+0.103	+1.104	.002	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,496 associations by consensus.

Regulation of protein localization to mitochondrion by GPR68 expression — SOFT_TISSUE

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