GPR68

Across TCGA cell cohorts, GPR68 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR68-associated genes across cancer lineages are RBMY1A1, IFNA8, and ACER1. Each is linked with GPR68 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR68-to-partner and partner-to-GPR68 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1A1 grouped by GPR68-low versus GPR68-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR68→partner) and Y-score (partner→GPR68) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RBMY1A1 →	+0.143	+5.807	<.001	.001	3	1
SKIN	IFNA8 →	+0.039	+4.977	<.001	.007	3	1
SKIN	ACER1 →	+0.032	+4.977	<.001	.007	3	1
SKIN	OR11H6 →	+0.018	+4.977	<.001	.007	3	1
SKIN	TAS2R60 →	+0.092	+5.415	<.001	.004	3	1
SKIN	OR10S1 →	+0.132	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

RBMY1A1 by GPR68 expression — OVARY

Explore this box plot interactively →