GPR50

Across TCGA patient cohorts, GPR50 protein abundance is significantly associated with the RNA expression of many other genes, with 584 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GPR50-associated genes across cancer lineages are CIAO3, PANX1, and SPRY2. Each is linked with GPR50 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR50-to-partner and partner-to-GPR50 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPR50 versus CIAO3 in LSCC, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR50→partner) and Y-score (partner→GPR50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CIAO3 →	+0.555	+0.511	<.001	.003	3	1
LSCC	PANX1 →	-0.600	-0.485	.001	.006	3	1
LSCC	SPRY2 →	+1.405	+0.516	.001	.003	3	1
LSCC	C7orf25 →	-0.345	-0.480	.002	.007	3	1
LSCC	TENT5B →	-1.683	-0.514	.005	.004	3	1
LSCC	SYNJ1 →	-0.366	-0.514	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 584 associations by consensus.

GPR50 vs CIAO3 — LSCC

Explore this scatter interactively →