GPR50

Across TCGA pan-cancer cohorts, GPR50 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of GPR50’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GPR50 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPR50 is over-expressed in tumor, although a few such as BRCA and KIRC show the opposite, repressed pattern.

HNSC, LUSC, and BRCA are the cancer types where GPR50 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR50 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.607	<.001	9	view →
LUSC	Male	All	+1.284	<.001	5	view →
BRCA	All	III,IV	−0.195	.001	4	view →
KIRC	Male	All	−0.073	<.001	4	view →
KICH	Female	All	−0.181	.018	2	view →
KIRP	All	All	−0.067	.007	2	view →
STAD	Male	All	−0.065	.034	1	view →
STAD	Female	III,IV	+0.045	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 7 lineages.

GPR50–HNSC

Open the HNSC breakdown →