GPR50

Across TCGA patient cohorts, GPR50 mutation is significantly associated with the RNA expression of many other genes, with 3,435 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR50-associated genes across cancer lineages are RELA, SKA3, and CKAP2L. Each is linked with GPR50 in more than 3 cancer types. Because this analysis shows association rather than direction, both GPR50-to-partner and partner-to-GPR50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RELA grouped by GPR50-low versus GPR50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR50→partner) and Y-score (partner→GPR50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RELA →	+0.311	+1.545	.002	.005	3	4
SKCM	SKA3 →	+0.414	+1.791	.006	.006	3	3
SKCM	CKAP2L →	+0.536	+1.806	.001	.001	3	3
SKCM	C11orf68 →	+0.306	+1.546	.001	<.001	3	3
SKCM	PNPLA2 →	+0.328	+1.977	.001	<.001	3	3
UCEC	RIC8A →	+0.334	+2.695	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,435 associations by consensus.

RELA by GPR50 expression — UCEC

Explore this box plot interactively →