GPR45

Across TCGA cell cohorts, GPR45 mutation is significantly associated with the RNA expression of many other genes, with 488 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR45-associated genes across cancer lineages are IL17F, KHDC3L, and SLC35G4. Each is linked with GPR45 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR45-to-partner and partner-to-GPR45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL17F grouped by GPR45-low versus GPR45-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR45→partner) and Y-score (partner→GPR45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IL17F →	+0.094	+3.977	<.001	.005	3	1
LUNG_NSCLC_LUAD	KHDC3L →	+0.028	+4.215	<.001	.002	3	1
LUNG_NSCLC_LUAD	SLC35G4 →	+0.018	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	PBOV1 →	+0.022	+3.760	.003	.008	3	1
LARGE_INTESTINE	GCAT →	+1.452	+3.628	<.001	<.001	3	1
LARGE_INTESTINE	RPL3 →	+0.465	+3.067	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 488 associations by consensus.

IL17F by GPR45 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →