GPR45

Across TCGA pan-cancer cohorts, GPR45 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated GPR45 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GPR45 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GPR45 expression acts as an unfavorable survival marker, although some lineages such as UCS and LGG show a favorable association.

KIRC, KICH, and MESO are the cancer types where GPR45 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.834	0.922	<.001	66	view →
KICH	DFS	Tertile	II,III,IV	0.463	1.000	.003	46	view →
MESO	DFS	Quartile	III,IV	0.247	0.499	.009	44	view →
UCS	DFS	Median	IV	0.952	0.367	.001	44	view →
LGG	DFS	Median	All	0.458	0.293	<.001	39	view →
PAAD	DFS	Tertile	All	0.505	0.235	.002	32	view →
LAML	DFS	Median	All	0.479	0.265	.006	24	view →
ACC	DFS	Quartile	All	0.215	0.545	.007	22	view →
UVM	DFS	Median	III,IV	0.270	0.623	.005	11	view →
HNSC	OS	Median	III,IV	0.725	0.597	.018	9	view →
READ	DFS	Quartile	All	0.240	0.759	.005	8	view →
TGCT	DFS	Median	II,III,IV	0.765	1.000	.036	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GPR45–KIRC (OS)

Open the KIRC breakdown →