GPR35

Across TCGA patient cohorts, GPR35 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR35-associated genes across cancer lineages are VHL, IRS1, and p62 Lck ligand. Each is linked with GPR35 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR35-to-partner and partner-to-GPR35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by GPR35-low versus GPR35-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR35→partner) and Y-score (partner→GPR35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.671	-2.321	.019	.034	3	2
UCEC	IRS1 →	+0.198	+1.700	.024	.044	3	1
UCEC	p62 Lck ligand →	+0.364	+2.469	.008	.010	3	1
UCEC	Rab11 →	-0.129	-1.700	.035	.044	3	1
UCEC	Bak →	+0.254	+3.584	.017	.002	3	1
UCEC	Caspase-8 →	-0.311	-2.906	.003	.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

VHL by GPR35 expression — UCEC

Explore this box plot interactively →