GPR35

Across TCGA pan-cancer cohorts, GPR35 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GPR35 data layer compared with 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GPR35 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GPR35 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, ACC, and SKCM are the cancer types where GPR35 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.750	0.621	<.001	138	view →
ACC	DFS	Median	All	0.334	0.815	<.001	109	view →
SKCM	OS	Quartile	II,III,IV	0.477	0.268	.001	47	view →
LUAD	DFS	Tertile	III,IV	0.431	0.818	.001	42	view →
BLCA	OS	Tertile	II,III,IV	0.781	0.638	.003	36	view →
DLBC	OS	Median	All	0.733	1.000	.003	36	view →
LGG	DFS	Quartile	All	0.647	0.867	<.001	34	view →
PRAD	DFS	Median	All	0.810	0.950	<.001	26	view →
OV	OS	Quartile	III,IV	0.759	0.887	.009	24	view →
LAML	DFS	Tertile	All	0.218	0.499	.004	20	view →
THYM	DFS	Median	All	0.970	0.834	.012	17	view →
ESCA	OS	Median	All	0.617	1.000	.009	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GPR35–HNSC (DFS)

Open the HNSC breakdown →