GPR35

Across TCGA pan-cancer cohorts, GPR35 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of GPR35’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GPR35 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPR35 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and STAD are the cancer types where GPR35 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR35 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.265	<.001	12	view →
COAD	All	IV	+1.062	<.001	10	view →
STAD	All	II,III,IV	+1.818	<.001	9	view →
LUAD	Male	II,III,IV	+1.493	<.001	7	view →
LIHC	Female	All	+1.361	<.001	7	view →
KICH	All	All	−0.602	<.001	7	view →
CHOL	Male	All	+3.333	<.001	4	view →
READ	Female	All	+1.532	.002	4	view →
ESCA	All	II,III,IV	+3.705	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

GPR35–KIRC

Open the KIRC breakdown →