GPR35

Across TCGA cell cohorts, GPR35 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GPR35-associated genes across cancer lineages are TMCO5A, OR4N2, and RBMY1J. Each is linked with GPR35 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR35-to-partner and partner-to-GPR35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMCO5A grouped by GPR35-low versus GPR35-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR35→partner) and Y-score (partner→GPR35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1
SKIN	OR4N2 →	+0.164	+4.977	<.001	.007	3	1
SKIN	RBMY1J →	+0.006	+4.977	<.001	.007	3	1
SKIN	OR5V1 →	+0.016	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TMCO5A by GPR35 expression — LARGE_INTESTINE

Explore this box plot interactively →