GPR17

Across TCGA patient cohorts, GPR17 mutation is significantly associated with the RNA expression of many other genes, with 2,771 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR17-associated genes across cancer lineages are RNU4-85P, FAM155A-IT1, and OR4D11. Each is linked with GPR17 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR17-to-partner and partner-to-GPR17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-85P grouped by GPR17-low versus GPR17-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR17→partner) and Y-score (partner→GPR17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU4-85P →	+0.250	+3.314	<.001	.002	3	2
COAD	FAM155A-IT1 →	+0.252	+3.541	<.001	<.001	3	2
BLCA	OR4D11 →	+0.045	+7.307	<.001	<.001	3	2
CESC	OR52A1 →	+0.029	+6.837	<.001	<.001	3	2
UCEC	PKN3 →	+0.743	+2.885	<.001	<.001	3	2
UCEC	SSTR5 →	+0.493	+1.986	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,771 associations by consensus.

RNU4-85P by GPR17 expression — COAD

Explore this box plot interactively →