GPR17

Across TCGA pan-cancer cohorts, GPR17 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated GPR17 data layer compared with 6 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher GPR17 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GPR17 expression acts as an unfavorable survival marker, although some lineages such as UVM and HNSC show a favorable association.

MESO, UVM, and HNSC are the cancer types where GPR17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	III,IV	0.287	0.600	.003	85	view →
UVM	OS	Tertile	All	0.907	0.394	<.001	83	view →
HNSC	DFS	Quartile	IV	0.473	0.247	<.001	54	view →
LGG	DFS	Median	All	0.471	0.315	<.001	44	view →
PAAD	DFS	Quartile	II,III,IV	0.493	0.325	.008	33	view →
SARC	OS	Median	All	0.916	0.733	<.001	32	view →
LIHC	OS	Quartile	All	0.739	0.556	.003	23	view →
READ	DFS	Median	All	0.399	0.721	.007	20	view →
SCLC	OS	Quartile	IV	0.164	0.584	.008	15	view →
UCEC	DFS	Median	All	0.867	0.923	.020	14	view →
LUAD	OS	Quartile	II,III,IV	0.584	0.298	.009	12	view →
CESC	OS	Quartile	IV	0.613	0.089	.028	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GPR17–MESO (OS)

Open the MESO breakdown →