GPR17

Across TCGA patient cohorts, GPR17 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR17-associated genes across cancer lineages are ASNS, IGFBP2, and MEK1. Each is linked with GPR17 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR17-to-partner and partner-to-GPR17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by GPR17-low versus GPR17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR17→partner) and Y-score (partner→GPR17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.510	+1.874	<.001	.049	3	3
UCEC	IGFBP2 →	-0.577	-1.678	.020	.023	3	2
UCEC	MEK1 →	+0.496	+3.906	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.151	-1.678	.009	.023	3	2
UCEC	Cyclin-B1 →	+0.660	+3.321	.002	.009	3	2
COAD	PDCD4 →	-0.465	-2.991	.033	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ASNS by GPR17 expression — UCEC

Explore this box plot interactively →