GPR17

Across TCGA cell cohorts, GPR17 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPR17-associated genes across cancer lineages are GALP, CSHL1, and FATE1. Each is linked with GPR17 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR17-to-partner and partner-to-GPR17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALP grouped by GPR17-low versus GPR17-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR17→partner) and Y-score (partner→GPR17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GALP →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	CSHL1 →	+0.032	+5.415	<.001	.004	3	1
BLOOD_Leukemia	FATE1 →	+0.134	+4.551	<.001	.004	3	1
BLOOD_Leukemia	TMEM244 →	+0.346	+4.551	<.001	.004	3	1
BLOOD_Leukemia	PNLIPRP3 →	+0.010	+4.551	.001	.004	3	1
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GALP by GPR17 expression — SKIN

Explore this box plot interactively →