GPR161

Across TCGA patient cohorts, GPR161 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR161-associated genes across cancer lineages are Annexin-1, C-Raf, and eIF4E. Each is linked with GPR161 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR161-to-partner and partner-to-GPR161 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by GPR161-low versus GPR161-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR161→partner) and Y-score (partner→GPR161) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.702	+3.906	<.001	<.001	3	2
UCEC	C-Raf →	+0.144	+2.115	.006	.017	3	2
UCEC	eIF4E →	+0.184	+2.222	.017	.010	3	1
UCEC	ERK2 →	+0.168	+1.874	.017	.049	3	1
UCEC	Heregulin →	-0.099	-2.308	.028	.033	3	1
UCEC	Lck →	+0.165	+2.459	.025	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Annexin-1 by GPR161 expression — UCEC

Explore this box plot interactively →