GPR161

Across TCGA pan-cancer cohorts, GPR161 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated GPR161 data layer compared with 11 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher GPR161 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GPR161 expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

MESO, ACC, and KIRP are the cancer types where GPR161 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.251	0.515	<.001	114	view →
ACC	DFS	Median	All	0.265	0.622	<.001	105	view →
KIRP	DFS	Median	All	0.784	0.917	<.001	96	view →
HNSC	DFS	Tertile	IV	0.431	0.195	<.001	66	view →
SKCM	OS	Median	III,IV	0.283	0.536	<.001	51	view →
COAD	DFS	Tertile	All	0.703	0.857	.003	25	view →
OV	DFS	Median	All	0.415	0.345	.016	22	view →
GBM	DFS	Tertile	All	0.472	0.173	.002	21	view →
CESC	DFS	Quartile	All	0.356	0.674	.019	14	view →
KIRC	DFS	Median	All	0.856	0.735	.010	14	view →
PRAD	DFS	Quartile	All	0.908	0.773	.002	14	view →
BLCA	DFS	Median	All	0.193	0.491	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GPR161–MESO (OS)

Open the MESO breakdown →