GPR161

Across TCGA pan-cancer cohorts, GPR161 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GPR161’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GPR161 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPR161 is over-expressed in tumor, although a few such as UCEC and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where GPR161 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR161 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.759	<.001	11	view →
THCA	All	All	+0.602	<.001	7	view →
LIHC	Female	II,III,IV	+0.385	<.001	7	view →
UCEC	All	All	−1.750	<.001	6	view →
KIRC	All	All	+0.410	<.001	6	view →
CHOL	All	All	+1.738	<.001	5	view →
LUSC	All	All	+0.824	<.001	5	view →
KICH	All	All	−0.669	<.001	4	view →
BRCA	All	III,IV	−0.444	.013	4	view →
PRAD	All	All	−0.729	<.001	2	view →
READ	Female	All	−0.938	.047	1	view →
LUAD	Female	II,III,IV	−0.519	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GPR161–HNSC

Open the HNSC breakdown →