GPR161

Across TCGA cell cohorts, GPR161 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR161-associated genes across cancer lineages are GAGE12D, C16orf82, and GAGE12C. Each is linked with GPR161 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR161-to-partner and partner-to-GPR161 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12D grouped by GPR161-low versus GPR161-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR161→partner) and Y-score (partner→GPR161) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GAGE12D →	+3.483	+5.228	<.001	.005	3	2
LUNG_NSCLC_LUAD	C16orf82 →	+0.013	+5.662	<.001	.002	3	2
LUNG_NSCLC_LUAD	GAGE12C →	+2.203	+5.228	<.001	.005	3	2
LARGE_INTESTINE	FGF23 →	+0.388	+3.584	.002	.003	3	2
SOFT_TISSUE	CST9L →	+0.028	+5.369	<.001	.004	3	1
SOFT_TISSUE	RLN3 →	+0.059	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

GAGE12D by GPR161 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →