GPR149

Across TCGA patient cohorts, GPR149 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR149-associated genes across cancer lineages are TFRC, Caspase-7-cleavedD198, and Di-Ras3. Each is linked with GPR149 in more than 3 cancer types. Because this analysis shows association rather than direction, both GPR149-to-partner and partner-to-GPR149 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by GPR149-low versus GPR149-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR149→partner) and Y-score (partner→GPR149) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.527	+2.906	.001	.001	3	4
UCEC	Caspase-7-cleavedD198 →	+0.436	+1.945	.017	.002	3	3
UCEC	Di-Ras3 →	-0.164	-1.893	<.001	<.001	3	3
SKCM	Gab2 →	-0.441	-3.000	.010	.034	3	2
SKCM	IGFBP2 →	-0.483	-2.115	.029	.018	3	2
SKCM	53BP1 →	-0.361	-1.874	.026	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

TFRC by GPR149 expression — UCEC

Explore this box plot interactively →