GPR149

Across TCGA pan-cancer cohorts, GPR149 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated GPR149 data layer compared with 10 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher GPR149 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GPR149 expression acts as an unfavorable survival marker, although some lineages such as LGG and LUSC show a favorable association.

MESO, THYM, and ACC are the cancer types where GPR149 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.232	0.565	.001	108	view →
THYM	OS	Tertile	All	0.743	0.984	<.001	72	view →
ACC	OS	Tertile	All	0.252	0.754	.007	48	view →
KIRC	DFS	Tertile	All	0.632	0.830	<.001	42	view →
CHOL	DFS	Tertile	All	0.045	0.497	.029	36	view →
DLBC	DFS	Quartile	IV	0.169	0.834	.001	30	view →
COAD	DFS	Tertile	IV	0.193	0.502	.010	27	view →
THCA	OS	Tertile	IV	0.095	0.966	<.001	21	view →
SCLC	DFS	Median	All	0.590	0.939	.007	19	view →
LIHC	DFS	Tertile	III,IV	0.077	0.414	.004	18	view →
HNSC	OS	Median	All	0.266	0.490	.003	18	view →
LGG	DFS	Quartile	All	0.896	0.811	.006	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GPR149–MESO (OS)

Open the MESO breakdown →