GPR149

Across TCGA pan-cancer cohorts, GPR149 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of GPR149’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GPR149 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPR149 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

HNSC, COAD, and BRCA are the cancer types where GPR149 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR149 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.402	.004	8	view →
COAD	All	All	−0.041	<.001	8	view →
BRCA	All	III,IV	−0.081	<.001	6	view →
THCA	Female	All	−0.023	<.001	6	view →
LUSC	Male	All	+0.769	<.001	4	view →
STAD	All	All	−0.033	.001	4	view →
PRAD	All	All	−0.429	.001	2	view →
READ	All	All	−0.031	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

GPR149–HNSC

Open the HNSC breakdown →