GPR149

Across TCGA cell cohorts, GPR149 RNA expression is significantly associated with the go_rna of many other GO terms, with 269 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GPR149-associated GO terms across cancer lineages are Protein localization to condensed chromosome, Axonal transport of mitochondrion, and RNA splicing, via transesterification reactions. Each is linked with GPR149 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR149-to-partner and partner-to-GPR149 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to condensed chromosome grouped by GPR149-low versus GPR149-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR149→partner) and Y-score (partner→GPR149) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Protein localization to condensed chromosome →	+0.100	+0.381	<.001	.001	3	2
LUNG_SCLC	Axonal transport of mitochondrion →	+0.118	+0.400	.001	.002	3	2
LUNG_SCLC	RNA splicing, via transesterification reactions →	+0.058	+0.487	<.001	.003	3	2
LUNG_SCLC	Cell cycle phase transition →	+0.060	+0.434	<.001	<.001	3	2
LUNG_SCLC	Mitotic cell cycle phase transition →	+0.079	+0.542	<.001	<.001	3	2
LUNG_SCLC	Cell cycle G1/S phase transition →	+0.062	+0.440	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 269 associations by consensus.

Protein localization to condensed chromosome by GPR149 expression — LUNG_SCLC

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