GPR149

Across TCGA cell cohorts, GPR149 mutation is significantly associated with the RNA expression of many other genes, with 1,213 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR149-associated genes across cancer lineages are ADNP2, HDLBP, and PRPSAP2. Each is linked with GPR149 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR149-to-partner and partner-to-GPR149 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADNP2 grouped by GPR149-low versus GPR149-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR149→partner) and Y-score (partner→GPR149) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADNP2 →	+0.819	+2.043	<.001	.008	3	2
LARGE_INTESTINE	HDLBP →	+0.509	+2.043	.004	.008	3	2
LARGE_INTESTINE	PRPSAP2 →	+0.682	+2.523	<.001	.003	3	2
LARGE_INTESTINE	NFIC →	+1.362	+2.743	<.001	.001	3	2
LARGE_INTESTINE	RAB33B →	+0.547	+2.043	.002	.008	3	2
LARGE_INTESTINE	CRLF3 →	+0.520	+3.169	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,213 associations by consensus.

ADNP2 by GPR149 expression — LARGE_INTESTINE

Explore this box plot interactively →