GPR142

Across TCGA patient cohorts, GPR142 mutation is significantly associated with the RNA expression of many other genes, with 1,613 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR142-associated genes across cancer lineages are COX6CP17, TRIM25, and SCGB1C2. Each is linked with GPR142 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR142-to-partner and partner-to-GPR142 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6CP17 grouped by GPR142-low versus GPR142-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR142→partner) and Y-score (partner→GPR142) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COX6CP17 →	+0.442	+4.459	<.001	.005	3	3
UCEC	TRIM25 →	+0.387	+2.616	.004	.005	3	3
STAD	SCGB1C2 →	+0.314	+4.252	<.001	.003	3	3
SKCM	CHAF1B →	+0.491	+2.270	.004	.005	3	3
UCEC	NCAPH2 →	+0.557	+2.201	<.001	<.001	3	3
UCEC	CHAF1A →	+0.557	+1.895	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,613 associations by consensus.

COX6CP17 by GPR142 expression — GBM

Explore this box plot interactively →