GPR142

Across TCGA pan-cancer cohorts, GPR142 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated GPR142 data layer compared with 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GPR142 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GPR142 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCS show a favorable association.

UCEC, KIRP, and SKCM are the cancer types where GPR142 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.529	0.772	.001	92	view →
KIRP	OS	Tertile	All	0.348	0.756	<.001	80	view →
SKCM	DFS	Tertile	II,III,IV	0.347	0.180	.001	54	view →
UCS	DFS	Tertile	III,IV	0.547	0.100	<.001	52	view →
PAAD	DFS	Tertile	II,III,IV	0.526	0.237	.001	46	view →
LIHC	OS	Median	II,III,IV	0.838	0.479	.001	39	view →
SCLC	DFS	Quartile	All	0.550	0.255	.006	29	view →
BRCA	OS	Median	III,IV	0.881	0.774	.009	27	view →
STAD	DFS	Median	All	0.494	0.610	.010	27	view →
DLBC	DFS	Tertile	III,IV	0.074	0.984	.017	27	view →
LAML	DFS	Quartile	All	0.295	0.621	.020	22	view →
HNSC	DFS	Median	IV	0.446	0.304	.004	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GPR142–UCEC (OS)

Open the UCEC breakdown →