GPR142

Across TCGA pan-cancer cohorts, GPR142 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of GPR142’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GPR142 RNA is repressed in tumor relative to normal tissue. In most cancer types GPR142 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and BRCA are the cancer types where GPR142 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR142 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−1.264	<.001	11	view →
COAD	Female	II,III,IV	−0.342	<.001	10	view →
BRCA	All	III,IV	−0.254	<.001	6	view →
UCEC	All	All	−0.194	.001	4	view →
KIRC	All	All	+0.027	.002	2	view →
READ	All	All	−0.228	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

GPR142–THCA

Open the THCA breakdown →