GPR142

Across TCGA cell cohorts, GPR142 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GPR142-associated genes across cancer lineages are PDHA2, AVP, and OR10Q1. Each is linked with GPR142 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR142-to-partner and partner-to-GPR142 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDHA2 grouped by GPR142-low versus GPR142-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR142→partner) and Y-score (partner→GPR142) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PDHA2 →	+0.062	+4.662	<.001	.005	3	2
LARGE_INTESTINE	AVP →	+0.068	+4.217	<.001	.001	3	1
LARGE_INTESTINE	OR10Q1 →	+0.110	+3.920	.001	.005	3	1
LARGE_INTESTINE	TRDN →	+0.040	+4.054	<.001	.004	3	1
LARGE_INTESTINE	LRRC3C →	+0.395	+3.777	<.001	.007	3	1
LUNG_NSCLC_LUAD	CD1C →	+0.033	+4.212	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

PDHA2 by GPR142 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →