GPR137C

Across TCGA patient cohorts, GPR137C mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR137C-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and FASN. Each is linked with GPR137C in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR137C-to-partner and partner-to-GPR137C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GPR137C-low versus GPR137C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR137C→partner) and Y-score (partner→GPR137C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.295	-3.169	.009	.019	3	1
UCEC	A-Raf_pS299 →	-0.170	-2.321	.001	.034	3	1
UCEC	FASN →	+0.460	+2.000	.009	.032	3	1
UCEC	ACC_pS79 →	+0.414	+2.000	.008	.032	3	1
UCEC	GATA6 →	-0.140	-2.693	.044	.006	3	1
UCEC	ACC1 →	+0.448	+3.013	.006	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

EGFR_pY1068 by GPR137C expression — UCEC

Explore this box plot interactively →