GPR135

Across TCGA patient cohorts, GPR135 mutation is significantly associated with the RNA expression of many other genes, with 1,270 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR135-associated genes across cancer lineages are RN7SL248P, GSKIP, and GRPEL1. Each is linked with GPR135 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR135-to-partner and partner-to-GPR135 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by GPR135-low versus GPR135-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR135→partner) and Y-score (partner→GPR135) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.051	+2.985	<.001	.006	3	2
UCEC	GSKIP →	+0.413	+2.230	.008	.006	3	2
UCEC	GRPEL1 →	+0.338	+3.839	.007	<.001	3	2
UCEC	BNIP1 →	+0.334	+2.753	.001	.002	3	2
UCEC	TNFSF9 →	+0.908	+2.736	<.001	<.001	3	2
UCEC	TXNDC17 →	+0.453	+2.736	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,270 associations by consensus.

RN7SL248P by GPR135 expression — UCEC

Explore this box plot interactively →