GPR135

Across TCGA pan-cancer cohorts, GPR135 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated GPR135 data layer compared with 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GPR135 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPR135 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BRCA show a favorable association.

COAD, MESO, and UVM are the cancer types where GPR135 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.616	0.782	<.001	70	view →
MESO	OS	Quartile	All	0.256	0.537	.002	56	view →
UVM	DFS	Median	III,IV	0.350	0.731	.001	45	view →
BLCA	DFS	Quartile	All	0.483	0.631	.004	40	view →
KICH	DFS	Tertile	II,III,IV	0.432	1.000	.007	37	view →
KIRP	DFS	Tertile	All	0.343	0.784	.001	36	view →
SKCM	OS	Tertile	II,III,IV	0.334	0.184	.003	32	view →
BRCA	OS	Tertile	III,IV	0.905	0.727	.001	30	view →
SCLC	OS	Median	II,III,IV	1.000	0.462	.005	27	view →
HNSC	OS	Tertile	III,IV	0.585	0.895	.002	24	view →
STAD	DFS	Quartile	All	0.473	0.659	.009	24	view →
THYM	DFS	Tertile	All	1.000	0.580	.002	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GPR135–COAD (DFS)

Open the COAD breakdown →